What is the primary cause of Buphthalmia, also known as congenital glaucoma?

Buphthalmia, or congenital glaucoma, primarily arises from genetic factors that affect the development of the eye. Specifically, this condition is often linked to inherited abnormalities that disrupt the normal formation and function of the eye's drainage angle, leading to increased intraocular pressure. When this pressure is elevated, it can cause the eyeball to enlarge, resulting in the characteristic signs associated with Buphthalmia.

Genetic diseases can encompass a variety of specific genetic mutations or syndromes that are known to cause abnormal eye development, making this the most significant risk factor for the condition. Understanding the role of genetics is crucial for early diagnosis and management in affected individuals, as identifying hereditary patterns can aid in both treatment options and family planning for those who may be at risk.

The other options, while they might relate to different ocular conditions, do not specifically or primarily contribute to the development of congenital glaucoma as genetic factors do. This distinction highlights the importance of recognizing the genetic underpinnings of such eye disorders.